topsfield is right off Rt 95
so i'd go down Rt16/Spaulding turnpike to 95S. there are several options to get from Moult to Rt16/Spaulding, and since I live off Rt 95 I have tried them all.
smoothest/more miles, but not much slower: 25 E to 16S to spaulding
alternate: 25 E to 109 to 171E to Rt16/Spaulding (windy road - not good for motion sickness). Scenic
2nd alternate: 25E to 109S thru Wolfboro to 28S to 11 to Rt16/Spaulding
it is going to take you about 2.5 hours no matter how you slice it
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